With Messi out, Coutinho, Dembele must step up for Barcelona

Barcelona head coach Ernesto Valverde

Barcelona head coach Ernesto Valverde

However, he later left to have further tests done, a statement from Barcelona later confirming a fracture of his radius bone.

Ousmane Dembele came on for Messi, who had scored Barcelona's second goal on the evening before leaving the match.

Barcelona announced Messi's injury on their website late Saturday saying Barcelona's "number 10" can be out for approximately three weeks because of a fractured arm.

Barcelona beat Sevilla when the two sides met in the Spanish Super Cup back in August, and they made the flawless when Coutinho took Messi's ball and curled a trademark shot past Tomas Vaclik into the top corner.

He is now set to miss two Champions League games against Inter Milan as well as the Clasico and LaLiga games against Rayo Vallecano and Real Betis.

"Los Blaugrana" had a remarkable first 15 minutes, with two goals from Philippe Coutinho in the third minute, and Messi in the 13th, just before the Argentine was carried off.

"We had a great September before the global break and we had to win to stay on this path, so we could arrive at Barcelona with this mentality, which is very important for us", Icardi added.

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As Real Madrid are proving in the absence of Cristiano Ronaldo, a striker's goals are hard to replace but so too is the aura.

"Psychologically we know that when he is there we are stronger but we can not allow his absence to affect us", Piqué said. We all know what the opponent thinks when they play Leo.

Luis Suarez could sit out the game against Inter. Barcelona, meanwhile, seem to have sparked a rival.

When Barca went three matches without a win, he was dropped.

Real Madrid, who welcome them to the Bernabeu next weekend, are fifth after falling to another defeat - this time at home to Levante - earlier in the day.

The Argentina attacker will, therefore, be unavailable to face Inter in the Champions League on Wednesday, as well as missing next weekend's Clasico. "I think we are doing a good job, but there are many things we need to improve".

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